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pImuran tablets are used as an immunosuppressant antimetabolite either alone ormore commonlyin combination with other agentsusually corticosteroidsand procedures which influence the immune responseTherapeutic effect may be evident only after weeks or months and can include a steroid-sparing effectthereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids./ppInformation is available on the risk of malignancy with the use of IMURAN in rheumatoid arthritissee ADVERSE REACTIONSIt has not been possible to define the precise risk of malignancy due to IMURANThe data suggest the risk may be elevated in patients with rheumatoid arthritisthough lower than for renal transplant patientsHoweveracute myelogenous leukemia as well as solid tumors have been reported in patients with rheumatoid arthritis who have received IMURAN./ppPatients on IMURAN should have complete blood countsincluding platelet countsweekly during the first monthtwice monthly for the second and third months of treatmentthen monthly or more frequently if dosage alterations or other therapy changes are necessary./ppThe maintenance dosage required may range from less than 1 mg/kg bodyweight/day to 3 mg/kg bodyweight/daydepending on the clinical condition being treated and the individual patient responseincluding haematological tolerance./p

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it is recommended that a further dose reduction or alternative therapies be considered for patients with low or absent tpmt activity receiving imuran and allopurinol because both tpmt and xo inactivation pathways are affected.

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